The COVID-19 pandemic has disproportionately affected American Indian and Alaska Native (AI/AN) peoples from a health, economic, and spiritual perspective. In August 2020, rates of confirmed COVID-19 cases among AI/AN peoples were 3.5 times higher than non-Hispanic White populations [1]. AI/AN peoples are more likely to live in multigenerational households, making social distancing challenging [2]. Further, AI/AN individuals are more likely to have preexisting medical conditions that amplify the risk of severe COVID-19 disease, such as obesity and diabetes [3]. Such health inequities are rooted in hundreds of years of Western aggression, ranging from genocide to forced institutionalization (ie, boarding schools) that removed Indigenous peoples from protective cultural practices and perpetuated continuing oppression and socioeconomic inequities [4-7]. During the COVID-19 pandemic, health systems starved by years of federal underspending were called upon to treat a flood of cases of the novel virus [2,8]. Communities that have come together during hardship in sacred ceremony since time immemorial were urged and often mandated by tribal law to stay home, with traditional wisdom keepers at risk for severe disease [8].

Despite these layered challenges, tribal and urban Indian organizations showed remarkable agility and resilience in initiating and promoting mitigation measures such as curfews and social distancing orders that many adjacent non-AI/AN communities implemented briefly or not at all [8]. By the spring of 2021, when access to COVID-19 vaccines became widespread, uptake among AI/AN peoples was the highest of any US racial group, although there were variations across regions and tribal lands [9]. This high acceptance has been attributed to Indigenous values, including solidarity and respect for elders and other culture-bearers threatened by COVID-19 [10]. Innovative and highly varied approaches in delivering and encouraging vaccination were also successful within AI/AN communities [8-11].

To increase confidence in vaccines and other pandemic mitigation strategies, tribes and AI/AN organizations used culturally tailored messaging strategies. Communication campaigns highlighted cultural strengths such as reverence for elders and community members using slogans such as “Be a Good Relative” and “For the Love of Our People” [10,12]. Such campaigns often used social media to disseminate guidance and foster connectedness. Social media also aided in countering the marginalization and erasure of AI/AN peoples, sometimes omitted as a distinct population in national communications about the pandemic’s effects [12]. Prior to the pandemic, social media had provided a sense of power and control over Indigenous identities [13,14]. Now, forums such as the Facebook groups Social Distance Powwow and American Indian COVID-19 Resources and Response have helped participants celebrate traditional skills such as beading and dancing to cope with pandemic losses during a time of social isolation [15,16].

Pandemic-era communication campaigns targeting AI/AN communities used social media to disseminate guidance, meet community needs, and help people stay connected to protective culture and community [17]. Campaigns used proven public health communication strategies, such as engaging trusted leaders to deliver culturally adapted messaging [18]. However, evidence-based guidance on using social media to raise awareness about public health measures was limited at the start of the COVID-19 pandemic, particularly with regard to AI/AN communities. Social media outreach has substantial benefits, especially in the context of a rapidly evolving pandemic, by allowing for immediacy and the ability to forge rapid connections, build rapport with audiences, and dispel rumors by providing accurate information [19,20]. Limitations include the need to monitor channels for harmful misinformation—for instance, in negative comments, which can influence viewers’ opinions [21,22]. There is some evidence that well-designed social media campaigns may deliver a range of behavior change components, such as social support, observational learning, instructions on how to perform a behavior, and prompts or cues to practice a behavior [23]. Public health campaigns using social media have been linked with public health impact such as increases in human papillomavirus vaccination coverage and uptake of pre-exposure prophylaxis prescriptions [24,25]. To compete in dense and rapidly changing social media environments rife with misinformation, public health organizations must design social media campaigns using best practices and compare evidence about what works to reach and engage web-based audiences with protective health messaging [26].

The Johns Hopkins Center for Indigenous Health (CIH; The Bloomberg School’s Center for American Indian Health was renamed Center for Indigenous Health in September 2022) launched a COVID-19 communications campaign at the start of the pandemic in March 2020 and, over the next several months, established a social media presence to inform and connect tribes, urban Indian organizations, and community members with reliable, culturally adapted communication on evidence-based measures to slow the spread of the virus. CIH convened a Tribal Advisory Board (TAB) and engaged AI/AN colleagues based in Arizona, Maryland, Minnesota, New Mexico, and California to guide the social media campaign [27]. The campaign included hundreds of social media posts consisting of graphics, fact sheets, videos, and slideshows, covering topics including physical distancing, mental health, isolation and quarantine, masking, and vaccination and using a variety of tones and message styles. To acknowledge a collective perception of adversity, some posts used insider humor packaged as colorful memes that could be self-deprecating, satiric, or refreshingly silly; such messages were reviewed by the TAB prior to distribution, ensuring the voice, tone, and terms were appropriate for and understood by AI/AN peoples across the country. All social media materials were made available in Microsoft Word–based toolkits including graphics and supporting captions, available for download at a public resource library [28]. Applying guidance from the TAB, CIH’s social media campaign aimed to frame COVID-19 health information with accessible and engaging content featuring Indigenous illustrations and languages across Facebook, Instagram, and Twitter, which is the focus of this study. Although we could not limit our post reach to AI/AN-identifying audiences, to maximize visibility to AI/AN Twitter users, we mentioned leading national organizational accounts on most posts and used hashtags popular with AI/AN Twitter users.

On Twitter, posts reached increasingly larger audiences throughout the campaign, with some messages organically reaching tens of thousands of people. In November 2020 and May 2021, two Twitter Chats (live, open-discussion, and time-bound Twitter campaign events) were organized around, first, Native American Heritage Month, and second, the rollout of COVID-19 vaccines for people of all ages in the United States. Such events reached a relatively large audience, but other posts shared during the campaign achieved 100 or fewer impressions. The divergence in audience reach and impressions throughout the 1-year campaign demonstrated a need to better characterize the relationship between message characteristics and audience reach and engagement. This analysis aimed to describe the correlation of content themes with Twitter post performance in a health campaign aiming to inform AI/AN communities.

This study was reviewed by the Johns Hopkins University Institutional Review Board, which concluded it was not human subjects research since the study encompassed (1) key informant interviews, involving information from individuals about something other than themselves and disclosing no personal opinions; and (2) secondary data analysis.

To examine trends in social media messaging, our analysis focused on Twitter posts shared by CIH from July 1, 2020, to June 30, 2021—a 1-year campaign. During this time frame, CIH published 162 original campaign-related posts. Twitter analytics data were extracted from CIH’s Twitter account, and the analysis reviewed impressions (the number of times a given tweet is viewed); engagements (the number of times a user interacts with a tweet through retweets, favorites, replies, link clicks, hashtag clicks, mention clicks, and media views); and a summary indicator of engagement rate (ER), which measures the number of engagements a tweet has per impression.

To better understand and contextualize themes across Twitter posts, 10 key informant interviews with members of CIH’s TAB were conducted. The TAB was made up of AI/AN and allied health communication professionals from various regions. Meeting twice monthly, the TAB provided guidance on AI/AN public health priorities, reviewed health communications content produced by CIH, and sought to ensure that campaign content was culturally appropriate and relevant across Indian Country. Thus, their feedback shaped all content produced for the Twitter campaign analyzed in this paper.

Key informant interviews with TAB members were conducted by a member of the study team as part of a separate evaluation of the TAB procedures using a semistructured interview guide. Participants were female professionals serving in communications and outreach roles for tribal nations and other organizations serving AI/AN peoples, representing 12 tribes and 10 tribal-serving organizations across various regions; all but 2 identified as AI/AN. Interviews were audio recorded, transcribed, and analyzed by a member of the study team familiar with the data. Although interviews largely focused on participants’ experience in the TAB, passages related to social media strategy were compiled and applied to inform our analysis of Twitter posts.

To guide the analysis and interpretation of results, we used the Health Belief Model (HBM), a theory adapted to influence health behaviors that has been used in diverse cultural contexts since the 1950s [29]. The theory’s 6 constructs include risk susceptibility, risk severity, benefits to action, barriers to action, self-efficacy, and cues to action; the campaign messages aimed to leverage nearly all components [30]. In addition to themes from TAB interviews, risk communication guidance emphasizing the benefits of 2-way communication through social media was also applied to content analysis [19].

Twitter posts were iteratively coded by theme using both deductive content derived from the HBM and TAB interviews and inductive codes based on emergent themes. Thematic coding classified all Twitter posts into categories of similar messaging strategies. In this study, 2 members of the study team each independently coded a subset of 50 posts, initially using deductive themes and then creating additional inductive codes as appropriate. Codes were iteratively refined and combined to create overarching categories through discussion. After 3 revisions, the codebook was finalized, and 2 members of the study team coded all posts, resolving each discrepancy through reflexive discussion. These themes were then used as variables in the analysis of audience reach and engagement.

Data obtained from CIH’s Twitter account were first entered into R statistical software (version 4.0.3; R Foundation for Statistical Computing) [31]. An initial data exploration stage included data cleaning, in which variables were recategorized and examined for missingness. Data exploration was completed for several variables, including partner tagging, time of day, year and month, and type of post. All date-time variables were parsed to include only the month and year. “High” and “low” ER or impressions were classified through percentiles, in which all posts in the 75th percentile or above in either outcome were classified as “high” and those below the 75th percentile were classified as “low.” Initial descriptive statistics and figures were then used to examine the counts and distribution of posts across the variables of interest using the dplyr and ggplot packages [32,33]. Possible confounders and a priori variables were evaluated and selected for further analysis. Odds ratios were then calculated to examine the association between theme and impressions or ER; a generalized linear model was used to calculate the adjusted odds ratios. The odds ratios were adjusted for time of year (month and year), which was an a priori variable, to account for several factors over the year-long campaign: an increase in followers over time, a gradual increase in impressions per post, and a decline in average ER per post. Tweets of a particular type where n=1 were excluded from the analysis.

The process of coding Twitter posts led to 4 overarching categories, as seen in Multimedia Appendix 1. Of the 162 tweets, 75 (46.3%) were categorically coded as Framing Knowledge, 37 (22.8%) as Cultural Messaging, 24 (14.8%) as Normalizing COVID Mitigation Strategies, and 26 (16%) as Interactive Opportunities. Under these 4 categories, the data revealed 10 themes: Perceived Susceptibility, Perceived Severity, Perceived Benefits, Self-Efficacy, Indigenous Value Systems, Humor, Social Norms, Observational Learning, Event Promotion, and Twitter Chat (see Multimedia Appendix 1). Definitions and examples of tweets coded within each category and theme are shown in Multimedia Appendix 1.

CIH’s Twitter account had 900 followers as of February 23, 2021—near the middle of the campaign—which increased to 1200 followers by its end. Throughout the campaign, posts organically generated 425,834 impressions and 6016 engagements. On average, each post received 2628 impressions and 37 engagements, with an average ER of 2.2%. Figures 1 and 2 display the distribution of impressions and ER by the post theme, highlighting initial summary statistics and the density of the distribution. In our data exploration phase, several variables—partner tagging, time of day, and type of post—were not found to be significant and were thus excluded from consideration in the adjusted analysis.

Table 1 describes post themes and associations with impressions, before and after an adjustment for the date the posts were published. Prior to adjusting for month of posting, posts coded with the theme Observational Learning had 5.01 (95% CI 1.36-20.57) times the odds of achieving high impressions than other posts. After adjusting, Event Promotion posts had 6.79 (95% CI 1.75-32.27) times the odds of being among the top 75% of tweets by impressions than other posts, and Twitter Chat messages had 15.94 (95% CI 3.12-138.42) times the odds of achieving high impressions. The post with the greatest number of impressions (n=22,039) was a Twitter Chat welcome message about COVID-19 vaccinations in AI/AN communities (Figure 3). The post with the second highest number of impressions (n=21,309) featured a video with a Navajo traditional healer speaking about her decision to get vaccinated against COVID-19, coded as Observational Learning (Figure 3). The reverse trend was observed for posts that were coded as Self-Efficacy and Social Norms, with these posts having 0.04 (95% CI 0.002-0.31) times and 0.17 (95% CI 0.002-0.73) times the odds of achieving high impressions than other themes.

Posts thematically coded under Self-Efficacy and Humor were statistically more likely to generate a high ER, with Self-Efficacy posts having 2.95 (95% CI 1.27-6.84) times and Humor posts having 5.43 (95% CI 1.43-20.70) times the odds of being in the high percentile for ER (Table 2). The post with the highest ER (9%) explained how to wear masks to protect against COVID-19, with simple graphics illustrating masks offering poor protection, such as bandanas, and masks offering good protection, such as disposable surgical masks (Figure 3). An example of a high-ER Humor post (ER 6%) was an AI/AN-drawn cartoon of a man with a feather chasing a SARS-CoV-2 particle with a giant syringe, under a headline that read, “Don’t Stop Now—It’s on the Run!” (Figure 3). The post themes associated with having a higher number of impressions in our adjusted analysis, Event Promotions and Twitter Chats, were not more likely to generate higher ER.

This study thematically analyzed Twitter posts from a COVID-19 communications campaign prioritizing AI/AN audiences to understand how best to reach and engage audiences with pandemic mitigation guidance. The study organized posts into 4 categories and 10 themes that integrated the HBM and risk communication guidance with Indigenous cultural values such as solidarity and humor. On average, posts that highlighted interactive opportunities to learn about and discuss pandemic and cultural issues were likely to reach more people but were not associated with higher engagement. Posts highlighting cultural role models such as traditional healers and web-based influencers often reached high numbers of people, although this finding did not remain significant after adjustment. In contrast, posts that highlighted instructional content with simple graphics or used insider humor to convey pandemic-related guidance were more likely to create high ER but, on average, reached fewer accounts.

In all, 99 (61.1%) out of 162 posts were coded with themes from the HBM, demonstrating that this theory was a strong fit for coding posts. An additional 37 (22.8%) posts were coded with cultural themes, appealing to traditional identities that are vital to the well-being of AI/AN peoples, as demonstrated by their protective effect on binge substance use, suicide attempts, and other major health risks [34,35]. Within these cultural themes, 10 posts were thematically coded as Humor. Finally, the Interactive Opportunities theme highlighted 2-way communication aiming to augment community connectedness and increase public health transparency during an uncertain time [36].

In our statistical analysis of theme by impressions, we found that posts highlighting web-based events were more likely to achieve a higher reach. Twitter Chats have been a successful strategy to build community for other public health organizations, practitioners, and health advocacy groups [37-39]. The high number of impressions for Twitter Chat messaging in this campaign could reflect interaction with other AI/AN–serving organizations as these messages were promoted and shared with a larger audience base. Thus, encouraging 2-way communication in our campaign was successful in reaching more users even if individual users were not as likely to engage directly with campaign posts.

In our study, posts highlighting role models (ie, Observational Learning) were not associated with high impressions after adjusting for the date of posting. This finding runs in contrast to evidence from a variety of community contexts, including a campaign reaching tribal audiences, that posts sharing personal stories from trusted messengers can successfully engage audiences [24,40-44]. However, given the importance of storytelling in AI/AN communities, we feel that highlighting trusted role models is critical to successful communication campaigns and warrants future implementation and evaluation within AI/AN contexts.

Audience engagement varied substantially during the campaign, with a reported average ER of 2.2% and a median ER of 1.9% during the 1-year campaign. Although engagement metrics vary by social media platform, industry, and topic, an industry source estimates that nonprofit posts on Twitter average an ER of 0.05% [45]. There is very limited evidence related to Twitter campaigns targeting AI/AN community members, but an evaluation of an AI/AN-oriented obesity prevention campaign observed that social media posts “generated little involvement and response,” and a campaign addressing kidney donation found community members did not engage with Twitter messages during the campaign [46,47]. More research is needed to inform the development of social media content to ensure adequate reach and engagement in AI/AN communities across a range of issues.

Thematically, humorous posts and those with instructional graphics were more likely to spur web-based activity. Other evaluations have found that visual concepts positively affect engagement behaviors, including in AI/AN-focused social media campaigns [48,49]. Our finding that humorous posts were more likely to achieve high ER is bolstered by evidence that scientific visualizations in humorous form can improve knowledge acquisition and problem-solving skills [50,51]. Further, humor has special salience in AI/AN communities as a source of resilience to hardship. Individuals have a great deal of institutional mistrust and may use humor in code switching [52,53]. Across a variety of Indigenous cultures worldwide, humor demonstrates cultural understanding, whereas speaking familiarly and using terms recognized to be of Indigenous origin, such as “Stoodis” and “Skoden”—as the CIH campaign did—can build confidence that messages are coming from within the community [54]. The strategic use of humor in social media messaging also builds upon AI/AN oral traditions such as “Trickster” stories [54]. Humor can also be a powerful tool for building trust in health care relationships [55,56]. Humorous social media content, therefore, has an important role in culturally competent communication strategies, especially around sensitive health topics. Using humor may destigmatize disparities, stimulate discussion, and prompt care-seeking where appropriate. Social media campaigns aiming to reach AI/AN audiences should consider using audience-tailored humor to convey empathy and humility while ensuring cultural appropriateness.

Over the course of the 1-year campaign, the average number of impressions generated per post increased and the average ER declined, potentially showing that the larger audiences the campaign reached later were on average less likely to take action to share or amplify a message they saw. This finding may reflect natural tension between impressions and ER, due to their reciprocal relationship; outside of COVID-19, other campaigns have also found a trade-off between impressions and engagement [41]. This finding also may reflect changes in public sentiment over time; as the pandemic became less novel, community members may have felt less urgency to reshare guidance. Increased burnout and COVID-19 fatigue may have reduced engagement with pandemic-related guidance.

Our findings may be instructive for others seeking to promote culturally tailored content for AI/AN audiences on social media. Social media activity should be integrated into multimodel communication campaigns designed to reach all community members, including those on tribal lands where broadband internet limitations persist [57,58]. Increasing access to high-speed internet in rural AI/AN communities will contribute to the increased relevance of social media communication in the future [58,59].

Although there are differences across social media networks, findings should be relatable to campaigns conducted across numerous platforms. For example, campaigns on Facebook or Instagram incorporating humorous content and highly visual, instructional guidance may be successful in achieving higher performance metrics than those using other types of content, such as posts explaining the benefits of public health measures, which may seem too conventional to engage savvy web-based audiences. This analysis focused on Twitter as the most consistent CIH social media platform throughout the pandemic. Campaign performance metrics on Facebook were highly variable during the time period and thus differences in reach and engagement may not be attributable to the salience of particular thematic content with our audience [60,61]. Meanwhile, CIH’s Instagram account, being newly established, saw lower performance measures than on Facebook or Twitter. Future research should focus on whether Twitter-based findings remain consistent across other platforms, especially with variation in user characteristics across different platforms [62].

We sought to explore social media metrics during the peak of the COVID-19 pandemic and thus, focused on a limited data set to capture reach and engagement to reflect this unique period of time. Our relatively small data set produced parameters with broad confidence intervals, which limits the strength of the quantitative findings. We integrated only 1 confounding factor in the adjusted analysis, date of posting, and other confounders may be unaccounted for, although other factors we reviewed did not seem to affect performance metrics.

Although the CIH campaign achieved nearly a half-million impressions, the total number of AI/AN peoples in the United States is 9.7 million [63]. The prevalence of social media use among AI/AN peoples is likely similar to that among the general population at around 70% [62,64]. Therefore, the campaign’s Twitter posts did not reach a significant proportion of AI/AN social media users in the United States. Additionally, due to data privacy around social media users, it is impossible to verify that those reached by CIH posts were AI/AN. By engaging and cross-promoting content with prominent AI/AN users and organizations, such as through Twitter Chats, we assume that a large proportion of users reached were AI/AN. However, this is a limitation inherent to all studies using social media analytics data for publicly targeted campaigns.

Finally, given the vast diversity across 574 federally recognized tribes and urban AI/AN communities, our findings may not be widely applicable across all AI/AN audiences. The TAB that supervised the development of the campaign and informed this thematic analysis was representative of a variety of tribes and regions but was almost entirely made up of early-to-midcareer professional women. The perspective of other stakeholders such as male leaders may be underrepresented.

AI/AN communities have been disproportionately affected by the COVID-19 pandemic. Social media offered a medium to rapidly provide public health guidance and foster cultural connectedness to counteract the isolation and marginalization of Indigenous experiences within the pandemic. Awareness campaigns using social media can benefit from integrating effective strategies to reach and engage increasingly active AI/AN audiences on platforms such as Twitter. In a 1-year social media campaign to disseminate guidance on COVID-19, posts highlighting opportunities for web-based discussion were, on average, likely to reach larger audiences. Humorous tweets and posts with simple, instructional graphics were 2 leading ways to engage audiences by demonstrating humility and promoting confidence in public health guidance as well as encouraging the adoption of preventive behaviors. Further analysis across other social media platforms is needed to inform organizations and tribes seeking to disseminate public health guidance to AI/AN communities.